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RGLAX PHARMARglax Coat

SC-401

Transparent seal coat and pre-coat

Clear sub-coat laid down before an enteric layer on acid labile cores.

Application

Transparent layer seal coat or pre-coat applied ahead of an enteric coat, specified for the Pantoprazole group. It isolates the core from the enteric polymer and gives the functional layer a uniform surface to build on.

Formulated for

  • Pantoprazole group

How it runs

Applied on the film coating band rather than the enteric one, before the functional layer goes on. Keep the layer thin. Its job is to isolate the core from the enteric polymer and to give the functional film an even surface, not to cover.

Build-up and solids are fixed at trial.

Part of the Seal and Pre-Coat range.

Product code
SC-401
Coating system
Seal and Pre-Coat
Process base
Aqueous or non-aqueous
Finish
Transparent
Supply form
Ready-mix, dispersed on site

How the coat sits on the tablet

Seal or pre-coatTransparent or pigmentedTablet coreCompressed active and excipientsCross-section, not to scale
A sub-coat gives the functional layer an even surface to build on, and keeps the core away from the polymer above it.

Starting parameters

Rglax Coat film coating

Tablet bed and inlet temperatures are given as aqueous over non-aqueous (AQ / NAQ). Settings are indicative and confirmed against your core during trials.

Coating equipmentConventional coaterAQ / NAQ12 inch panAuto coaterAQ / NAQ24 inch panConventional coaterAQ / NAQ36 inch panAuto coaterAQ / NAQ48 inch pan
Pan speed (rpm)18 to 2014 to 168 to 123 to 5
Tablet charge (kg)0.5 to 13 to 540 to 50100 to 130
Tablet bed temp (°C)35-40 / 30-3535-40 / 30-3535-40 / 30-3535-40 / 30-35
Inlet temp (°C)75-80 / 60-6575-80 / 60-6575-80 / 60-6575-80 / 60-65

Common questions about SC-401

When is a seal coat needed before an enteric layer?

On acid labile cores, the Pantoprazole group in particular. SC-401 isolates the core from the enteric polymer and gives the functional film an even surface to build on.

How thick should the seal layer be?

Thin. Its job is to isolate, not to cover. Where the sub-coat also has to hide a dark or mottled core, SC-501 is the grade to use instead.