EC714
Enteric coat, CAP base
Cellulose acetate phthalate enteric film for Diclofenac and Serratiopeptidase.
Application
CAP base enteric coating material for Diclofenac and Serratiopeptidase enteric tablets. It is the alternative polymer route to ECM-RP348 where a CAP film is specified.
Formulated for
- Diclofenac
- Serratiopeptidase
How it runs
The same cool enteric band as the methacrylic grades. Choose it over ECM-RP348 where a CAP film is specified in your filing, since the two are formulated for the same actives by different polymer routes.
Build-up and solids are fixed at trial.
The polymer
Cellulose acetate phthalate (CAP, CAP base)
CAP is the older of the enteric polymers and is still named in many filings. Where your dossier specifies a CAP film, the methacrylic route is not a substitution you can make without a change control, which is why we hold a CAP grade for the same actives.
Part of the Enteric Coating System range.
- Product code
- EC714
- Coating system
- Enteric Coating System
- Process base
- Non-aqueous (solvent)
- Finish
- Enteric film, gastro resistant
- Supply form
- Ready-mix, dispersed on site
How the coat sits on the tablet
Starting parameters
Rglax Coat enteric coating
Bed temperature is held low through the functional layer, which protects the polymer film. Settings are indicative and confirmed against your core during trials.
| Coating equipment | Conventional coater12 inch pan | Auto coater24 inch pan | Conventional coater36 inch pan | Auto coater48 inch pan |
|---|---|---|---|---|
| Pan speed (rpm) | 18 to 20 | 10 to 14 | 8 to 12 | 3 to 5 |
| Tablet charge (kg) | 0.5 to 1 | 3 to 5 | 40 to 50 | 100 to 130 |
| Tablet bed temp (°C) | 30 to 32 | 30 to 32 | 30 to 32 | 30 to 32 |
| Inlet temp (°C) | 45 to 50 | 45 to 50 | 45 to 50 | 45 to 50 |
Common questions about EC714
When should EC714 be chosen over ECM-RP348?
When a CAP film is specified in your filing. Both grades are formulated for Diclofenac and Serratiopeptidase enteric tablets, but EC714 builds the film on cellulose acetate phthalate rather than a methacrylic polymer.
What temperature does it run at?
The standard enteric band. Bed at 30 to 32 degrees, inlet at 45 to 50, across every pan size from 12 to 48 inch.