ECM-RP347
Enteric coat, methacrylic base, non-aqueous
Solvent base methacrylic enteric film for the Pantoprazole group.
Application
Methacrylic base enteric coating applied from a non-aqueous system, formulated for the Pantoprazole group and other dissolution critical enteric tablets. It runs best over a transparent seal coat such as SC-401, which protects the acid labile core.
Formulated for
- Pantoprazole group
How it runs
Lay SC-401 down first as a transparent seal, then apply the enteric film over it. The enteric stage runs cool throughout, around 30 to 32 degrees at the bed against a 45 to 50 degree inlet, because a hot bed softens the polymer and the finished film loses gastro resistance. Non-aqueous, so solvent handling applies to the functional stage.
Build-up and solids are fixed at trial.
The polymer
Methacrylic acid copolymer (methacrylic base, acrylic enteric polymer)
Methacrylic acid copolymers stay intact in the stomach and dissolve once pH rises in the intestine. They carry most of the enteric range because they can be applied from either a solvent or a water base, which lets the same polymer family serve cores that can and cannot tolerate an aqueous process.
Part of the Enteric Coating System range.
- Product code
- ECM-RP347
- Coating system
- Enteric Coating System
- Process base
- Non-aqueous (solvent)
- Finish
- Enteric film, gastro resistant
- Supply form
- Ready-mix, dispersed on site
How the coat sits on the tablet
Starting parameters
Rglax Coat enteric coating
Bed temperature is held low through the functional layer, which protects the polymer film. Settings are indicative and confirmed against your core during trials.
| Coating equipment | Conventional coater12 inch pan | Auto coater24 inch pan | Conventional coater36 inch pan | Auto coater48 inch pan |
|---|---|---|---|---|
| Pan speed (rpm) | 18 to 20 | 10 to 14 | 8 to 12 | 3 to 5 |
| Tablet charge (kg) | 0.5 to 1 | 3 to 5 | 40 to 50 | 100 to 130 |
| Tablet bed temp (°C) | 30 to 32 | 30 to 32 | 30 to 32 | 30 to 32 |
| Inlet temp (°C) | 45 to 50 | 45 to 50 | 45 to 50 | 45 to 50 |
Common questions about ECM-RP347
Does ECM-RP347 need a seal coat underneath?
Yes for the Pantoprazole group. Lay SC-401 down first as a transparent seal, then apply the enteric film over it. The seal isolates the acid labile core from the enteric polymer and gives the functional layer an even surface to build on.
Can it run on a 24 inch conventional coater?
Yes. At 24 inch the pan runs at 10 to 14 rpm with a 3 to 5 kg charge. Hold the bed at 30 to 32 degrees against a 45 to 50 degree inlet, the same as every other grade in the enteric range.
Is it aqueous or solvent based?
Solvent based. It is a methacrylic film applied from a non-aqueous system, so solvent handling and area classification apply to the enteric stage. Where your core allows a water base process, ECM-RP348 is the aqueous equivalent.