ECPT5
Enteric coat, phthalate base
Phthalate base enteric system for Duloxetine enteric tablets.
Application
Phthalate base enteric coating material formulated for Duloxetine enteric tablets, where the release profile is governed by the phthalate polymer rather than a methacrylic film.
Formulated for
- Duloxetine
How it runs
Runs on the cool enteric band alongside the methacrylic grades. Because release is governed by the phthalate polymer rather than a methacrylic film, confirm both the acid stage and the buffer stage on the first trial batch rather than carrying over a profile from another enteric product.
Build-up and solids are fixed at trial.
The polymer
Phthalate base polymer (HPMC phthalate, phthalate enteric polymer)
A phthalate base governs release differently from a methacrylic film, so a dissolution profile developed on one does not carry across to the other. Confirm the acid stage and the buffer stage on the first trial batch.
Part of the Enteric Coating System range.
- Product code
- ECPT5
- Coating system
- Enteric Coating System
- Process base
- Non-aqueous (solvent)
- Finish
- Enteric film, gastro resistant
- Supply form
- Ready-mix, dispersed on site
How the coat sits on the tablet
Starting parameters
Rglax Coat enteric coating
Bed temperature is held low through the functional layer, which protects the polymer film. Settings are indicative and confirmed against your core during trials.
| Coating equipment | Conventional coater12 inch pan | Auto coater24 inch pan | Conventional coater36 inch pan | Auto coater48 inch pan |
|---|---|---|---|---|
| Pan speed (rpm) | 18 to 20 | 10 to 14 | 8 to 12 | 3 to 5 |
| Tablet charge (kg) | 0.5 to 1 | 3 to 5 | 40 to 50 | 100 to 130 |
| Tablet bed temp (°C) | 30 to 32 | 30 to 32 | 30 to 32 | 30 to 32 |
| Inlet temp (°C) | 45 to 50 | 45 to 50 | 45 to 50 | 45 to 50 |
Common questions about ECPT5
What is ECPT5 formulated for?
Duloxetine enteric tablets. Release is governed by a phthalate base polymer rather than a methacrylic film, which is why it is a separate grade rather than a shade of the methacrylic range.
Can a profile from another enteric grade be carried over?
No. Because the polymer differs, confirm both the acid stage and the buffer stage on the first trial batch instead of carrying over a dissolution profile from a methacrylic enteric product.