RT314
Dissolution enhancer blend
Corrects disintegration time and dissolution where the core falls short.
Application
Dissolution enhancer blend used as DT and dissolution material. It is added where a core formulation does not meet the specified disintegration time or dissolution profile and reformulating the core is not practical.
How it runs
Added at the blending stage. Run disintegration and dissolution before and after addition on the same core, so you can show the correction came from the blend rather than from batch variation.
Build-up and solids are fixed at trial.
Part of the Dissolution Profile Material range.
- Product code
- RT314
- Coating system
- Dissolution Profile Material
- Process base
- Dry blend
- Finish
- Excipient blend
- Supply form
- Ready-mix, dispersed on site
How the coat sits on the tablet
Common questions about RT314
When is a dissolution enhancer the right fix?
When the core does not meet the specified disintegration time or dissolution profile and reformulating the core is not practical. It is added at the blending stage rather than applied as a coat.
How do we show the correction came from RT314?
Run disintegration and dissolution before and after addition on the same core. That separates the effect of the blend from ordinary batch to batch variation.
Does RT314 replace reformulating the core?
It is used where reformulating is not practical. If the core has a deeper problem than disintegration time, the blend corrects the symptom rather than the cause, and reformulation is still the better answer.