HR100
Hygroscopic adsorbent material
Holds moisture off hygroscopic actives during compression and afterwards.
Application
HR100 is a hygroscopic adsorbent material for hygroscopic drugs. It works effectively on Sodium Valproate, L-Carnitine, Valproate Sodium and other actives that pick up moisture and create problems during compression and afterwards.
Formulated for
- Sodium Valproate
- L-Carnitine
- Valproate Sodium
How it runs
Added at the blending stage ahead of compression. Where a hygroscopic active shows as sticking, picking or capping on the press, HR100 is worth trying before reworking the granulation, since it addresses the moisture rather than the binder system.
Build-up and solids are fixed at trial.
Part of the Hygroscopic Adsorbent range.
- Product code
- HR100
- Coating system
- Hygroscopic Adsorbent
- Process base
- Dry blend
- Finish
- Excipient blend
- Supply form
- Ready-mix, dispersed on site
How the coat sits on the tablet
Common questions about HR100
Which actives does HR100 work on?
Sodium Valproate, L-Carnitine, Valproate Sodium and other hygroscopic drugs that pick up moisture and create problems during compression and afterwards.
Is it a coating?
No. It is added at the blending stage ahead of compression. Where a hygroscopic active shows as sticking, picking or capping on the press, it is worth trying before reworking the granulation, because it addresses the moisture rather than the binder system.
Can HR100 be used together with a moisture barrier coat?
Yes, and they solve different halves of the problem. HR100 handles moisture in the powder before and during compression. A barrier film such as MB 31RP or CVS-101 protects the finished tablet afterwards. A hygroscopic active that fights the press and then degrades on shelf needs both.
What does a hygroscopic active look like on the press?
Sticking, picking and capping are the usual signs, and they get worse as the shift goes on and ambient humidity rises. If the granulation was sound and the trouble started with the active, the moisture is the thing to address first.