SR100
Sustained release material
Ready-mix blend for extended release solid dosage forms.
Application
Sustained release material for controlled release drug delivery systems. It is supplied as a ready-mix so the release profile is reproducible batch to batch without in-house polymer blending.
How it runs
Release rate follows the amount applied, which makes weight gain the control variable for this grade. It is fixed at the trial against your target dissolution profile rather than taken from a table, then held batch to batch.
Build-up and solids are fixed at trial.
Part of the Sustained Release System range.
- Product code
- SR100
- Coating system
- Sustained Release System
- Process base
- Dry blend
- Finish
- Functional release layer
- Supply form
- Ready-mix, dispersed on site
How the coat sits on the tablet
Starting parameters
Rglax Coat film coating
Tablet bed and inlet temperatures are given as aqueous over non-aqueous (AQ / NAQ). Settings are indicative and confirmed against your core during trials.
| Coating equipment | Conventional coaterAQ / NAQ12 inch pan | Auto coaterAQ / NAQ24 inch pan | Conventional coaterAQ / NAQ36 inch pan | Auto coaterAQ / NAQ48 inch pan |
|---|---|---|---|---|
| Pan speed (rpm) | 18 to 20 | 14 to 16 | 8 to 12 | 3 to 5 |
| Tablet charge (kg) | 0.5 to 1 | 3 to 5 | 40 to 50 | 100 to 130 |
| Tablet bed temp (°C) | 35-40 / 30-35 | 35-40 / 30-35 | 35-40 / 30-35 | 35-40 / 30-35 |
| Inlet temp (°C) | 75-80 / 60-65 | 75-80 / 60-65 | 75-80 / 60-65 | 75-80 / 60-65 |
Common questions about SR100
What controls the release rate with SR100?
Weight gain. Release rate follows the amount applied, so the build-up is the control variable. It is fixed at trial against your target dissolution profile, then held batch to batch.
Why supply it as a ready-mix?
Because in-house polymer blending is where extended release profiles drift between batches. A ready-mix removes that variable, so the profile you qualified is the profile you keep.