CVS-101
Moisture barrier for Amoxycillin and Clavulanate
Solvent base extra white barrier film for the most moisture sensitive combination.
Application
Moisture barrier film coat on a solvent base, extra white, developed for Amoxycillin and Clavulanate potassium tablets. Water ingress during and after coating drives degradation in that combination, and this grade is built to hold it out.
Formulated for
- Amoxycillin and Clavulanate potassium
How it runs
Solvent base, so the cooler non-aqueous band applies. With Amoxycillin and Clavulanate the exposure that matters is not only the spray. Plan the stage so coated tablets move to blistering without a long open hold, since the barrier film protects the core in the pack rather than repairing moisture already picked up.
Build-up and solids are fixed at trial.
The polymer
Polyvinyl alcohol (PVA)
PVA films are less permeable to water vapour than HPMC at the same thickness, which is what makes a moisture barrier a barrier. Our moisture barrier grades are fully formulated HPMC and PVA based immediate release systems, so the protection does not come at the cost of release.
Part of the Moisture Barrier Coating range.
- Product code
- CVS-101
- Coating system
- Moisture Barrier Coating
- Process base
- Non-aqueous (solvent)
- Finish
- Extra white, moisture barrier
- Supply form
- Ready-mix, dispersed on site
How the coat sits on the tablet
Starting parameters
Rglax Coat film coating
Tablet bed and inlet temperatures are given as aqueous over non-aqueous (AQ / NAQ). Settings are indicative and confirmed against your core during trials.
| Coating equipment | Conventional coaterAQ / NAQ12 inch pan | Auto coaterAQ / NAQ24 inch pan | Conventional coaterAQ / NAQ36 inch pan | Auto coaterAQ / NAQ48 inch pan |
|---|---|---|---|---|
| Pan speed (rpm) | 18 to 20 | 14 to 16 | 8 to 12 | 3 to 5 |
| Tablet charge (kg) | 0.5 to 1 | 3 to 5 | 40 to 50 | 100 to 130 |
| Tablet bed temp (°C) | 35-40 / 30-35 | 35-40 / 30-35 | 35-40 / 30-35 | 35-40 / 30-35 |
| Inlet temp (°C) | 75-80 / 60-65 | 75-80 / 60-65 | 75-80 / 60-65 | 75-80 / 60-65 |
Common questions about CVS-101
Is CVS-101 suitable for Amoxycillin and Clavulanate tablets?
That is what it was developed for. It is a solvent base extra white moisture barrier built for the combination, where water ingress during and after coating drives degradation.
Does the coating alone protect the tablet?
No. The barrier film protects the core inside the pack, it does not repair moisture already picked up. Plan the stage so coated tablets move to blistering without a long open hold.