Hygroscopic Adsorbent
An adsorbent for hygroscopic actives such as Sodium Valproate and L-Carnitine that stick, pick and cap on the press.
What this range covers
HR100 is a hygroscopic adsorbent material for hygroscopic drugs. It works effectively on Sodium Valproate, L-Carnitine, Valproate Sodium and other actives that create problems during compression and afterwards.
Actives covered by grades in this range
- Sodium Valproate
- L-Carnitine
- Valproate Sodium
- Grades in range
- 1
- Process base
- Dry blend
- Brand
- Rglax Coat
- Made at
- Tahliwal, Distt. Una, H.P.
1 grade in this range
Each grade has its own page with the application, the process notes and the questions buyers ask about it.
Common questions
Which actives does HR100 work on?
Sodium Valproate, L-Carnitine, Valproate Sodium and other hygroscopic drugs that pick up moisture and create problems during compression and afterwards.
Is it a coating?
No. It is added at the blending stage ahead of compression. Where a hygroscopic active shows as sticking, picking or capping on the press, it is worth trying before reworking the granulation, because it addresses the moisture rather than the binder system.
Can HR100 be used together with a moisture barrier coat?
Yes, and they solve different halves of the problem. HR100 handles moisture in the powder before and during compression. A barrier film such as MB 31RP or CVS-101 protects the finished tablet afterwards. A hygroscopic active that fights the press and then degrades on shelf needs both.
What does a hygroscopic active look like on the press?
Sticking, picking and capping are the usual signs, and they get worse as the shift goes on and ambient humidity rises. If the granulation was sound and the trouble started with the active, the moisture is the thing to address first.
Before you specify a grade
The polymers behind a coating system
Methacrylic, CAP, phthalate, HPMC and PVA. What each does in a film, and which grade is built on it.
Read the guideCoating defects and what causes them
Logo bridging, picking, orange peel, loss of gastro resistance and the failures that only show on stability.
Read the guide